SUCCESSFUL TREATMENT OF TWO CASES WITH PHILADELPHIA-CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA WHO RELAPSED AFTER ALLOGENEIC STEM CELL TRANSPLANTATION AND THE TREATMENTS WITH NOVEL IMMUNOTHERAPIES AND PONATINIB

The outcomes of relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) resistant to new drugs such as tyrosine kinase inhibitors, inotuzumab ozogamicin (InO) and Leather Long Wallet blinatumomab are dismal.We treated two cases of Ph+ALL resistant to these drugs that achieved long-term survival after treatment with chimeric

Abstract Background Clearly stated national recommendations for physical activity (PA) are available in many nations.Yet, their impact on national level policy-making might be considered modest at best.This paper analyses the approach selected to curtail this problem in Germany.Main text Academics, government institutions and relevant stakeholders

Abstract The family Baetiscidae Edmunds & Traver, 1954 is recognisable among mayflies due to its bizarre larvae, equipped with a robust and spiked thoracic notal shield covering part of the abdomen up to sixth segment.Originally being described as extant species from the USA and Canada, Baetiscidae were later found in the fossil record as well, spe

A new species of the genus Ripipteryx (Orthoptera: Tridactyloidea: Ripipterygidae) from the Toledo District of southern Belize is described and illustrated.Ripipteryx mopana sp.n.is placed in the Scrofulosa Group based on Data Transfer Cables its elaborately ornamented frons and is readily distinguished from its congeners by the fusion of the super

Russia has favorable conditions for development of hybrid cooperation (franchising) on the different markets.On the one hand, as well as for the majority of countries with transition economies many Russian markets has been undersaturated.On the other hand, as for the developed countries, Russia has highly skilled human resources and the developed s